HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
Bioorg Med Chem Lett
; 19(15): 4476-9, 2009 Aug 01.
Article
de En
| MEDLINE
| ID: mdl-19502055
ABSTRACT
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antiviraux
/
Benzothiadiazines
/
Hépatite C
/
Protéines virales non structurales
/
Antienzymes
/
Naphtalènes
/
Naphtols
Limites:
Animals
/
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2009
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique