ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?
APMIS Suppl
; (127): 21-6, 2009 Jun.
Article
de En
| MEDLINE
| ID: mdl-19515135
ABSTRACT
Anti-neutrophil cytoplasmic autoantibodies (ANCA) with a specificity for myeloperoxidase or proteinase 3 are closely associated with small vessel vasculitides (SVV). In vitro, ANCA activate primed neutrophils to release toxic substances that destroy endothelial cells, suggesting a pathogenic role for these autoantibodies in disease development. However, to study the complex interplay between ANCA, neutrophils, and the local environment in vivo, animal models are required. Here, we will review the animal models developed for ANCA-SVV and discuss how these models have been applied to study ANCA-SVV pathogenesis. In addition, some directions for future research pertaining to unresolved issues relevant for the pathogenesis and immunogenesis of ANCA-SVV are proposed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vascularite
/
Anticorps anti-cytoplasme des polynucléaires neutrophiles
/
Modèles animaux de maladie humaine
Limites:
Animals
/
Humans
Langue:
En
Journal:
APMIS Suppl
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
/
PATOLOGIA
Année:
2009
Type de document:
Article
Pays d'affiliation:
Pays-Bas