Nine-step enantioselective total synthesis of (+)-minfiensine.
J Am Chem Soc
; 131(38): 13606-7, 2009 Sep 30.
Article
de En
| MEDLINE
| ID: mdl-19725517
ABSTRACT
An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system. This total synthesis of (+)-minfiensine was completed in nine chemical steps and 21% overall yield.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carbazoles
Langue:
En
Journal:
J Am Chem Soc
Année:
2009
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique