Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats.
Biomed Res
; 30(4): 259-61, 2009 Aug.
Article
de En
| MEDLINE
| ID: mdl-19729857
ABSTRACT
We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight, and bromodeoxyuridine incorporation in the intestine on day 13 following the first injection. Administration of anti-GLP-2 serum significantly inhibited both epithelial proliferation in the distal ileum and elongation of the small intestine. These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Glucagon-like peptide 2
/
Iléum
/
Sérums immuns
/
Muqueuse intestinale
Limites:
Animals
Langue:
En
Journal:
Biomed Res
Année:
2009
Type de document:
Article
Pays d'affiliation:
Japon