Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.
Clin Vaccine Immunol
; 16(11): 1696-9, 2009 Nov.
Article
de En
| MEDLINE
| ID: mdl-19759250
ABSTRACT
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus Sindbis
/
Bacillus anthracis
/
Toxines bactériennes
/
Ciprofloxacine
/
Vaccins anticharbonneux
/
Vecteurs génétiques
/
Maladie du charbon
/
Antibactériens
/
Antigènes bactériens
Limites:
Animals
/
Humans
Langue:
En
Journal:
Clin Vaccine Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Année:
2009
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique