Local enkephalins tonically modulate dopamine release in the striatum: a microdialysis study.
Brain Res
; 524(1): 153-5, 1990 Jul 30.
Article
de En
| MEDLINE
| ID: mdl-1976029
ABSTRACT
Kelatorphan, an inhibitor of the enkephalin-degrading enzymes, infused by microdialysis (10(-6) M) in the striatum of anaesthetized rats, significantly increased dopamine (DA) output but left dihydroxyphenylacetic acid and homovanillic acid extracellular levels unchanged. The local application of naltrexone (10(-6) M) prevented the effect of kelatorphan on DA release. These data indicate that local enkephalins tonically modulate DA release in rat striatum.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dopamine
/
Corps strié
/
Dipeptides
/
Analgésiques
Limites:
Animals
Langue:
En
Journal:
Brain Res
Année:
1990
Type de document:
Article
Pays d'affiliation:
France