Effect of felbamate on plasma levels of carbamazepine and its metabolites.
Epilepsia
; 32(1): 130-2, 1991.
Article
de En
| MEDLINE
| ID: mdl-1985822
ABSTRACT
Felbamate (FBM) is a novel antiepileptic drug (AED) currently undergoing clinical evaluation in the United States. During a controlled clinical trial conducted at the National Institutes of Health Clinical Center, FBM was added to constant carbamazepine (CBZ) monotherapy. CBZ total concentrations were reduced during active FBM treatment (mean reduction 25%, range 10-42%, p less than 0.001). The effect was evident after the first week of treatment and reached a plateau in 2-4 weeks. To clarify the interaction mechanism, free and total concentrations of CBZ and its plasma metabolites were determined by high-performance liquid chromatography (HPLC) and ultrafiltration in four patients. In these patients, FBM treatment reduced CBZ concentrations and increased CBZ-epoxide (CBZ-E) concentrations (p less than 0.01). Free fractions of all compounds were unmodified. FBM appears to be capable of inducing CBZ metabolism. CBZ-FBM interaction may be clinically relevant.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Propylène glycols
/
Carbamazépine
/
Anticonvulsivants
Type d'étude:
Clinical_trials
Limites:
Humans
Langue:
En
Journal:
Epilepsia
Année:
1991
Type de document:
Article