tRNA-nucleotidyltransferases: highly unusual RNA polymerases with vital functions.
FEBS Lett
; 584(2): 297-302, 2010 Jan 21.
Article
de En
| MEDLINE
| ID: mdl-19883645
ABSTRACT
tRNA-nucleotidyltransferases are fascinating and unusual RNA polymerases responsible for the synthesis of the nucleotide triplet CCA at the 3'-terminus of tRNAs. As this CCA end represents an essential functional element for aminoacylation and translation, these polymerases (CCA-adding enzymes) are of vital importance in all organisms. With a possible origin of ancient telomerase-like activity, the CCA-adding enzymes obviously emerged twice during evolution, leading to structurally different, but functionally identical enzymes. The evolution as well as the unique polymerization features of these interesting proteins will be discussed in this review.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
RNA nucleotidyltransferases
/
DNA-directed RNA polymerases
Langue:
En
Journal:
FEBS Lett
Année:
2010
Type de document:
Article
Pays d'affiliation:
Allemagne