Detection of IFN-alpha produced in the presence of plasma gamma-globulin fraction proteins.
Bull Exp Biol Med
; 147(5): 613-6, 2009 May.
Article
de En, Ru
| MEDLINE
| ID: mdl-19907752
ABSTRACT
Interferon-alpha was detected in IFN pool produced by human leukocytes in the presence of gamma-globulin fraction proteins, copper and zinc cations, and metal-modified gamma-globulins. The cytokine appeared in culture medium at early terms (24 h) of incubation, is characterized by acid resistance, and is neutralized by antibodies to IFN-alpha. The content of IFN-alpha in supernatants of induced leukocytes reached 60-90 pg/ml and correlated with antiviral activity of the samples. Zinc bound to human serum gamma-globulin attenuated and copper stimulated the realization of IFN-inducing characteristics of the protein at early terms of incubation.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Gammaglobulines
/
Sérumalbumine
/
Sérum-globulines
/
Interféron alpha
/
Leucocytes
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
/
Ru
Journal:
Bull Exp Biol Med
Année:
2009
Type de document:
Article
Pays d'affiliation:
Russie