Globotriaosyl ceramide receptor function - where membrane structure and pathology intersect.
FEBS Lett
; 584(9): 1879-86, 2010 May 03.
Article
de En
| MEDLINE
| ID: mdl-19948172
ABSTRACT
The glycosphingolipid globotriaosyl ceramide, (Galalpha1-4Galss1-4 glucosyl ceramide-Gb(3)) also known as CD77 and the P(k) blood group antigen, is bound by both verotoxins and by the HIV adhesin, gp120. Gb(3) plays an important receptor role in VT induced hemolytic uremic syndrome (HUS) and HIV infection. The organization of glycolipids, including Gb(3), into lipid rafts is central to both pathologies. The fatty acid heterogeneity within the Gb(3) lipid moiety plays a central role in assembly within such ordered domains. Differential binding of verotoxins and gp120 to such Gb(3) isoforms in model and cell membranes indicates a significant role in the eventual pathogenic outcome. HUS may provide the first example whereby membrane Gb(3) organization provides a predictor for tissue selective in vivo pathology.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Trihexosylcéramide
/
Infections à VIH
/
Structures de la membrane cellulaire
/
Syndrome hémolytique et urémique
Type d'étude:
Etiology_studies
/
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
FEBS Lett
Année:
2010
Type de document:
Article
Pays d'affiliation:
Canada