Ronidazole toxicosis in 3 society finches (Lonchura striata).
Vet Pathol
; 47(2): 231-5, 2010 Mar.
Article
de En
| MEDLINE
| ID: mdl-20106792
ABSTRACT
A group of finches were accidentally overdosed with ronidazole, a 5-nitroimidazole used for treatment of trichomoniasis. Finches developed neurologic signs on the third day of treatment and were euthanized (or died). Three finches were submitted for necropsy. Focal necrosis of the cerebellar nucleus was seen in all 3 birds, as characterized by neuronal necrosis, vacuolation of the neuropil, gemistocytic astrocytosis, hemorrhage, and axonal swelling (spheroids) with demyelination. The liver from 1 finch was analyzed for ronidazole and its metabolite, 2-hydroxymethyl-1-methyl-5-nitroimidazole, by high-performance liquid chromatography-mass spectrometry. Ronidazole was detected in the liver tissue at 2,700 ng/g (wet weight), and 2-hydroxymethyl-1-methyl-5-nitroimidazole was detected at 140 ng/g (wet weight).
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ronidazole
/
Maladies des oiseaux
/
Fringillidae
/
Maladies du système nerveux
/
Antiprotozoaires
Limites:
Animals
Langue:
En
Journal:
Vet Pathol
Année:
2010
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique