Altered brain myelin sheath morphology after rewarming in situ.
Ultrastruct Pathol
; 34(2): 82-9, 2010 Apr.
Article
de En
| MEDLINE
| ID: mdl-20192705
ABSTRACT
In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13 degrees C). Animals held at 37 degrees C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100beta was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100beta (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lésions encéphaliques
/
Cerveau
/
Hypothermie provoquée
/
Gaine de myéline
Type d'étude:
Etiology_studies
/
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Ultrastruct Pathol
Année:
2010
Type de document:
Article
Pays d'affiliation:
Norvège