Acquired motor neuron loss causing severe pelvic limb contractures in a young cat.
J Feline Med Surg
; 12(3): 237-40, 2010 Mar.
Article
de En
| MEDLINE
| ID: mdl-20193915
ABSTRACT
PRESENTATION This report describes a kitten with paraplegia and extensor rigidity of the pelvic limbs associated with motor neuron loss and chronic denervation of skeletal muscle. Persistent skeletal muscle atrophy and degeneration had resulted in immobile stifle and hock joints and severe pelvic limb rigidity consistent with a neurogenic form of arthrogryposis. Both pelvic limbs were equally affected and the kitten showed no signs of pain. INVESTIGATIONS Electromyography identified spontaneous activity in the pelvic limbs. Muscle and peripheral nerve biopsies showed pathology consistent with denervation. On necropsy, 3 weeks after admittance, severe degenerative changes including axonal necrosis and myelin degeneration were confirmed in the lumbar spinal cord. CLINICAL RELEVANCE There are very few descriptions of feline motor neuron degeneration in the literature and obtaining an ante-mortem diagnosis is difficult. Although an inherited disorder cannot be ruled out, a condition acquired congenitally in utero or postnatally was suspected in this case.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Paraplégie
/
Amyotrophie spinale
/
Maladies des chats
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
J Feline Med Surg
Sujet du journal:
MEDICINA VETERINARIA
Année:
2010
Type de document:
Article
Pays d'affiliation:
Suède