Survey for the presence of BK, JC, KI, WU and Merkel cell polyomaviruses in human brain tissues.
J Clin Virol
; 48(1): 11-4, 2010 May.
Article
de En
| MEDLINE
| ID: mdl-20211582
ABSTRACT
BACKGROUND:
Recently three previously unknown polyomaviruses (KI, WU and Merkel cell polyomaviruses) have been identified from human specimens. The spectrum of clinical manifestations and their tissue tropism are currently unknown. Since a member of this virus family, JC virus, is well-known for its capacity to establish latency in human brain tissue where reactivation in immunocompromised individuals can result in fatal progressive multifocal leukoencephalopathy, we sought to examine for the presence of all the five known human polyomaviruses in a series of human brain tissues.OBJECTIVES:
To investigate the possibility of neuropersistence of the newly identified human polyomaviruses. STUDYDESIGN:
Autopsy brain tissues were collected from 10 different brain regions of 30 individuals who died from diseases unrelated to viral infections. Nested PCR was used to assess the presence or absence of viral DNA.RESULTS:
Ten samples collected from five individuals were found to harbour JCV DNA. In contrast, none of the 300 brain tissues examined showed positive results for BK, KI, WU or Merkel cell polyomavirus.CONCLUSION:
The newly identified KI, WU and Merkel cell polyomaviruses either do not, or have a much lower neuropersistent potential compared to JCV.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Polyomavirus
Type d'étude:
Prevalence_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Clin Virol
Sujet du journal:
VIROLOGIA
Année:
2010
Type de document:
Article