Nephrotoxicity of CDDP assessed estimating glomerular filtration rate with 99mTc-DTPA plasma sample method.
J Coll Physicians Surg Pak
; 20(2): 98-101, 2010 Feb.
Article
de En
| MEDLINE
| ID: mdl-20378036
ABSTRACT
OBJECTIVE:
To assess early nephrotoxicity of CDDP (Cis-diamminedichloroplatinum) manifested by a decline in the glomerular filtration rate (GFR) estimated by plasma two sample clearance method (PSC 2) after 99mTc-DTPA injection. STUDYDESIGN:
Descriptive study. PLACE AND DURATION OF STUDY Department of Nuclear Medicine, Karachi Institute of Radiotherapy and Nuclear Medicine, Karachi, from September 2004 to January 2005.METHODOLOGY:
The renal function was assessed on 36 patients suffering from different types of cancer and receiving CDDP in doses of (3) 50 mg/m(2) before and after in each of six CDDP cycles. The GFR was determined by PSC 2 method after 99mTc-DTPA injection). A paired sample t-test was used for comparison of the mean value with significance at p < 0.01.RESULTS:
There were (28 males and 8 females; age range being 16-68 years) The average decline in GFR baseline to the end of sixth cycles was 43.86 ml/min/1.73m(2) (p=0.000) as estimated by PSC 2 method. There was a significant fall of average 9.36 ml/min/1.73m(2) (p < 0.01) in GFR as observed in each cycle of CDDP estimated by the PSC 2 method. In the initial four cycles, CDDP produced a major nephrotoxic effect of average 10.27 ml/min/1.73m(2) (p < 0.01) fall in GFR. This then gradually declined to a plateau of an average decline in GFR of 7.76 and 7.31 ml/min/1.73m(2) (p=0.000) after the 5th and 6th cycle respectively.CONCLUSION:
CDDP produced an early nephrotoxicity which was manifested by a significant decline in GFR in each cycle. Tc-99m PSC 2 method for GFR estimation should be used periodically for the early detection of nephrotoxicity induced by CDDP.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pentétate de technétium (99mTc)
/
Cisplatine
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Radiopharmaceutiques
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Débit de filtration glomérulaire
/
Maladies du rein
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Antinéoplasiques
Type d'étude:
Screening_studies
Limites:
Adolescent
/
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
Langue:
En
Journal:
J Coll Physicians Surg Pak
Sujet du journal:
MEDICINA
Année:
2010
Type de document:
Article