Relevance of oral experimental challenge with classical scrapie in sheep.
J Gen Virol
; 91(Pt 8): 2139-2144, 2010 Aug.
Article
de En
| MEDLINE
| ID: mdl-20444991
ABSTRACT
Oral inoculation is currently considered as the best approach to mimic natural TSE contamination in ruminants. In this study, we compared the timing of abnormal prion protein (PrP(Sc)) dissemination and accumulation in the organism of susceptible sheep either orally inoculated or naturally infected with classical scrapie. Both animal groups shared a similar PrP(Sc) dissemination scheme and accumulation dynamics in lymphoid tissues. However, orally challenged animals displayed an earlier neuro-invasion and a dramatically shorter incubation period than naturally exposed sheep. No differences were observed between the groups with regards to the neuro-invasion route. These results unambiguously indicate that oral inoculation can have an impact on both the earliness of neuro-invasion and the incubation period. They also support the statement that oral inoculation is a relevant model for investigating transmissible spongiform encephalopathy pathogenesis. Nevertheless, data obtained under such experimental conditions should be used with some caution.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tremblante
/
Maladies des ovins
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
J Gen Virol
Année:
2010
Type de document:
Article
Pays d'affiliation:
France