[Effect of the I(f) channel blocker ivabradine on the parameters of external respiration function in patients with chronic obstructive pulmonary disease in its stable course period].
Ter Arkh
; 82(3): 23-5, 2010.
Article
de Ru
| MEDLINE
| ID: mdl-20564916
ABSTRACT
AIM:
To evaluate the effect of the I(f) channel blocker ivabradine on bronchial patency and the volume parameters of external respiration function in patients with chronic obstructive pulmonary disease (COPD) in remission in order to determine whether the drug may be used in patients with coronary heart disease (CHD) concurrent with COPD. SUBJECTS ANDMETHODS:
Heart rate, bronchial patency, and lung volume were studied by body plethysmography in 59 patients with COPD before and 14 days after administration of ivabradine in a daily dose of 10 mg.RESULTS:
The I(f) channel blocker ivabradine that is a highly selective bradycardiac agent fails to affect the velocity and volume parameters of external respiration function, thus it may be used to treat CHD concurrent with COPD.CONCLUSION:
The I(f) channel blocker ivabradine exerts no effect on external respiration function parameters (bronchial patency, volume parameters) and it can find clinical use in the treatment of angina pectoris and chronic heart failure in patients with CHD concurrent with COPD.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Respiration
/
Benzazépines
/
Agents cardiovasculaires
/
Broncho-pneumopathie chronique obstructive
/
Canaux cationiques contrôlés par les nucléotides cycliques
/
Rythme cardiaque
Type d'étude:
Prognostic_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
Ru
Journal:
Ter Arkh
Année:
2010
Type de document:
Article