A 7% decrease in the differential renal uptake of MAG3 implies a loss in renal function.
Urology
; 76(6): 1512-6, 2010 Dec.
Article
de En
| MEDLINE
| ID: mdl-20708778
ABSTRACT
OBJECTIVES:
To address the fact that a decrease in the relative renal uptake of 99mTc-mercaptoacetyltriglycine (MAG3) on serial MAG3 scans may indicate a loss of function and require a change in management by providing guidance as to what constitutes a meaningful change in serial relative function measurements as well determining the normal variation of other common MAG3 renogram parameters.METHODS:
A prospective study was conducted in 24 male urology patients with stable renal function. The mean age was 66.5 ± 7.9 (SD) years; the mean serum creatinine was 1.38 ± 0.57 (SD) mg/dL, and the MAG3 renal scans were performed a mean of 11 ± 8 days apart. Each MAG3 scan included a measurement of relative function as well as the time to maximum counts and 20 minutes to maximum count ratios for both cortical and whole kidney regions of interest.RESULTS:
The Pearson and intraclass correlations for the baseline and repeat measurements of relative renal function were both 0.98. Bland-Altman plots showed no bias between the baseline and repeat relative uptake measurements. The mean difference between 2 repeated measurements of the relative MAG3 uptake was 0.04 ± 2.88% (SD) for the left kidney and 0.08 ± 3.07% (SD) for the right kidney. Comparable results were obtained for the other renogram parameters.CONCLUSIONS:
Measurements of relative renal uptake of MAG3 and common renogram parameters are highly reproducible; a decrease in relative uptake ≥7% (ie, 50%-43%) implies a loss in renal function.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Mertiatide de technétium (99mTc)
/
Radiopharmaceutiques
/
Rein
/
Tests de la fonction rénale
Type d'étude:
Observational_studies
Limites:
Aged
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Urology
Année:
2010
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique