Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.
Bioorg Med Chem
; 18(18): 6785-95, 2010 Sep 15.
Article
de En
| MEDLINE
| ID: mdl-20708937
ABSTRACT
The Wnt pathway is involved in cellular processes linked to either proliferation or differentiation. Therefore small molecules offer an attractive opportunity to modulate this pathway, whereas the key enzyme GSK-3beta is of special interest. In this study, non-symmetrically substituted indolylmaleimides have been synthesized and their ability to function as GSK-3beta inhibitors has been investigated in a human neural progenitor cell line. Among the newly synthesized compounds, the substance IM-12 showed a significant activity in several biological tests which was comparable or even outplayed the effects of the known GSK-3beta inhibitor SB-216763. Furthermore the treatment of human neural progenitor cells with IM-12 resulted in an increase of neuronal cells. Therefore we conclude that indolylmaleimides act via the canonical Wnt signalling pathway by inhibition of the key enzyme GSK-3beta.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches
/
Glycogen Synthase Kinase 3
/
Inhibiteurs de protéines kinases
/
Indoles
/
Maléimides
/
Neurones
Limites:
Humans
Langue:
En
Journal:
Bioorg Med Chem
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2010
Type de document:
Article
Pays d'affiliation:
Allemagne