Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.
Br J Cancer
; 103(10): 1479-84, 2010 Nov 09.
Article
de En
| MEDLINE
| ID: mdl-20924377
ABSTRACT
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Somatomédines
/
Homéostasie
/
Insuline
/
Tumeurs
Limites:
Humans
Langue:
En
Journal:
Br J Cancer
Année:
2010
Type de document:
Article
Pays d'affiliation:
Autriche