Single-dose effects of isosorbide mononitrate alone or in combination with losartan on central blood pressure.
J Am Soc Hypertens
; 4(6): 311-8, 2010.
Article
de En
| MEDLINE
| ID: mdl-21130977
ABSTRACT
Antihypertensive drugs can have different effects on central and brachial blood pressures, which may affect outcomes. Nitric oxide donors have acute effects on central blood pressure but have not been assessed with renin-angiotensin system blockade. Thirteen patients with prehypertensive/Stage 1 hypertension were randomized to five single-dose treatments separated by ≤4 days using a double-blind, crossover study design:
angiotensin receptor blocker (ARB) losartan 100 mg, isosorbide mononitrate (ISMN) 60 mg, losartan 100 mg + ISMN 15 mg, losartan 100 mg + ISMN 60 mg, and placebo. Central and brachial blood pressures were measured throughout 10 hours. Mean placebo-subtracted decrease from baseline in augmentation index (AIx) approximately 1% for losartan 100 mg, 26% for ISMN 60 mg, 19% for losartan 100 mg + ISMN 15 mg, and 24% for losartan 100 mg + ISMN 60 mg. Administered with losartan 100 mg or alone, ISMN lowered AIx, demonstrating that acute effects of a nitrate donor are much larger than those of an ARB even when administered with an ARB. Differences from placebo were statistically significant except for losartan 100 mg. AIx is a good biomarker of acute hemodynamic effects of nitric oxide in prehypertensive/Stage 1 hypertension.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Losartan
/
Donneur d'oxyde nitrique
/
Antagonistes du récepteur de type 1 de l'angiotensine-II
/
Préhypertension
/
Hypertension artérielle
/
Dinitrate isosorbide
Type d'étude:
Clinical_trials
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Am Soc Hypertens
Sujet du journal:
ANGIOLOGIA
/
CARDIOLOGIA
Année:
2010
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique