Potent transglutaminase inhibitors, dithio ß-aminoethyl ketones.

Ozaki, Shoichiro; Ebisui, Etsuko; Hamada, Kozo; Suzuki, Akinobu Z; Terauchi, Akiko; Mikoshiba, Katsuhiko

Ozaki, Shoichiro; Ebisui, Etsuko; Hamada, Kozo; Suzuki, Akinobu Z; Terauchi, Akiko; Mikoshiba, Katsuhiko.

Affiliation

Ozaki S; Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Bioorg Med Chem Lett ; 21(1): 377-9, 2011 Jan 01.

Article de En | MEDLINE | ID: mdl-21134746

ABSTRACT

ABSTRACT

Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl ß-amino ketones.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transglutaminases / Antienzymes / Cétones Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2011 Type de document: Article Pays d'affiliation: Japon

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