[GABAergic mechanism of cerebrovasculareffect of mexidol].
Eksp Klin Farmakol
; 73(10): 11-3, 2010 Oct.
Article
de Ru
| MEDLINE
| ID: mdl-21254506
ABSTRACT
Experiments on rats showed that mexidol significantly increases local cerebral blood flow in animals under conditions of global transient brain ischemia, whereas in intact rats this drug initially causes a decrease in the blood flow, followed by its recovery. Mechanism of the cerebrovascular effect of mexidol is determined by its action on GABA receptors of cerebral vessels, which confirmed the fact that the cerebrovascular effect of mexidol is absent in the presence of bicuculline.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Picolines
/
Psychoanaleptiques
/
Circulation cérébrovasculaire
/
Récepteurs GABA
/
Acide gamma-amino-butyrique
Limites:
Animals
Langue:
Ru
Journal:
Eksp Klin Farmakol
Sujet du journal:
FARMACOLOGIA
Année:
2010
Type de document:
Article