Gender differences in serum CK-MB mass levels in healthy Brazilian subjects.
Braz J Med Biol Res
; 44(3): 236-9, 2011 Mar.
Article
de En
| MEDLINE
| ID: mdl-21271183
ABSTRACT
The creatine kinase-isoenzyme MB (CK-MB) mass assay is one of the laboratory tests used for the diagnosis of myocardial infarction. It is recommended, however, that reference limits should take gender and race into account. In the present study, we analyzed the plasma CK-MB mass and troponin levels of 244 healthy volunteers without a personal history of coronary artery disease and with no chronic diseases, muscular trauma or hypothyroidism, and not taking statins. The tests were performed with commercial kits, CK-MB mass turbo kit and Troponin I turbo kit, using the Immulite 1000 analyzer from Siemens Healthcare Diagnostic. The values were separated according to gender and showed significant differences by the Mann-Whitney test. Mean (± SD) CK-MB mass values were 2.55 ± 1.09 for women (N = 121; age = 41.20 ± 10.13 years) and 3.49 ± 1.41 ng/mL for men (N = 123; age = 38.16 ± 11.12 years). Gender-specific reference values at the 99th percentile level, according to the Medicalc statistical software, were 5.40 ng/mL for women and 7.13 ng/mL for men. The influence of race was not considered because of the high miscegenation of the Brazilian population. The CK-MB values obtained were higher than the 5.10 mg/mL proposed by the manufacturer of the laboratory kit. Therefore, decision limits should be related to population and gender in order to improve the specificity of this diagnostic tool, avoiding misclassification of patients.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troponine I
/
MB Creatine kinase
Type d'étude:
Prognostic_studies
Aspects:
Determinantes_sociais_saude
Limites:
Female
/
Humans
/
Male
Pays/Région comme sujet:
America do sul
/
Brasil
Langue:
En
Journal:
Braz J Med Biol Res
Année:
2011
Type de document:
Article
Pays d'affiliation:
Brésil