Radiological abnormalities associated with Aspergillus colonization in a cystic fibrosis population.
Eur J Radiol
; 81(3): e197-202, 2012 Mar.
Article
de En
| MEDLINE
| ID: mdl-21349668
ABSTRACT
OBJECTIVE:
To determine if sputum colonization with Aspergillus species in patients with cystic fibrosis (PWCF) correlates with radiological abnormalities and/or a reduction in pulmonary function (FEV1).METHODS:
We prospectively evaluated 32 PWCF utilizing high resolution computed tomography (HRCT) of the thorax and pulmonary function testing (PFT). The cohort was assessed as two groups Aspergillus positive (n=16) and Aspergillus negative (n=16) based on sputum culture for Aspergillus species. A modified Bhalla scoring system was applied to each HRCT scan by two blinded radiologists.RESULTS:
Aspergillus positive patients had more severe and significant bronchiectasis compared to those Aspergillus negative (p<0.05). This was most marked in the right upper and lower lobes (RUL, RLL). Total Bhalla score was clinically significant in both groups and approached statistical significance between groups (p=0.063). No difference in pulmonary function between the groups was detected.CONCLUSION:
PWCF colonized by Aspergillus species have greater radiological abnormalities undetectable by PFTs. Early radiological evaluation of Aspergillus colonized PWCF is therefore warranted.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Aspergillose
/
Dilatation des bronches
/
Tomodensitométrie
/
Mucoviscidose
Type d'étude:
Observational_studies
Limites:
Adolescent
/
Adult
/
Child
/
Humans
Langue:
En
Journal:
Eur J Radiol
Année:
2012
Type de document:
Article
Pays d'affiliation:
Royaume-Uni