Small molecules as friends and foes of the immune system.
Future Med Chem
; 1(9): 1583-91, 2009 Dec.
Article
de En
| MEDLINE
| ID: mdl-21425980
ABSTRACT
Every organism is in contact with numerous small molecules (<1000 Da). Chemicals may cause or trigger adverse health effects, including diseases of the immune system. They may also be exploited as drugs. In this review, we look at the interaction between small molecules and the immune system. We discuss the hapten and pharmacological interaction concepts of chemical interaction to trigger T cells and how chemicals can participate in cellular signaling pathways. As a sensor of small molecules, the arylhydrocarbon receptor controls expression of many xenobiotic metabolizing enzymes, including those in the immunological barrier organs; the skin and gut. The relevance of the arylhydrocarbon receptor in the dynamic interaction of the immune system with the chemical environment is therefore discussed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Système immunitaire
Langue:
En
Journal:
Future Med Chem
Année:
2009
Type de document:
Article
Pays d'affiliation:
Allemagne