Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF.
Neurobiol Learn Mem
; 96(2): 121-9, 2011 Sep.
Article
de En
| MEDLINE
| ID: mdl-21440650
ABSTRACT
Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA-BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Vieillissement
/
Activateur tissulaire du plasminogène
/
Facteur neurotrophique dérivé du cerveau
/
Environnement
/
Neurones
Type d'étude:
Risk_factors_studies
Limites:
Animals
Langue:
En
Journal:
Neurobiol Learn Mem
Sujet du journal:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
France