Differential diagnosis of IgM MGUS and WM according to B-lymphoid infiltration by morphology and flow cytometry.
Clin Lymphoma Myeloma Leuk
; 11(1): 93-5, 2011 Feb.
Article
de En
| MEDLINE
| ID: mdl-21454201
ABSTRACT
The distinction between IgM monoclonal gammopathy of undetermined significance (MGUS), asymptomatic Waldenstrom's macroglobulinemia (WM; aWM), and symptomatic WM (sWM) relies on two features the presence of infiltration by lymphoplasmacytic lymphoma in the bone marrow (BM) biopsy and the existence of signs or symptoms attributable to the disease. Nevertheless, some patients lack a BM biopsy or it is not conclusive for diagnosis. In this study we have investigated 94 patients with IgM monoclonal gammopathies, in which a BM trephine biopsy and morphological and flow cytometry (FCM) evaluation of BM aspirate were available at diagnosis. We found a clear correlation between BM infiltration of B-lymphocytes assessed by morphology and by FCM with a Pearson correlation of 0.62 (P<.001). Moreover, in the absence of a BM trephine biopsy, the cut-off points that would help in the differential diagnosis between MGUS, aWM, and sWM would be 20% for morphology and 5% for FCM, both assessed in the BM aspirate.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Gammapathie monoclonale de signification indéterminée
/
Immunoglobuline M
/
Lymphocytes B
/
Macroglobulinémie de Waldenström
/
Cytométrie en flux
Type d'étude:
Diagnostic_studies
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
Clin Lymphoma Myeloma Leuk
Sujet du journal:
NEOPLASIAS
Année:
2011
Type de document:
Article
Pays d'affiliation:
Espagne