Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways.
Chem Res Toxicol
; 24(6): 791-3, 2011 Jun 20.
Article
de En
| MEDLINE
| ID: mdl-21491947
ABSTRACT
Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Triméthoprime
/
Activation des lymphocytes
/
Hypersensibilité médicamenteuse
/
Anti-infectieux urinaires
Limites:
Adult
/
Female
/
Humans
Langue:
En
Journal:
Chem Res Toxicol
Sujet du journal:
TOXICOLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
Royaume-Uni