Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata.
J Nat Prod
; 74(5): 1335-8, 2011 May 27.
Article
de En
| MEDLINE
| ID: mdl-21513294
ABSTRACT
Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1-3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1-130 µM, with 2 being the most active (GI50 2.1-10 µM).
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Porifera
/
Sesquiterpènes
/
Antinéoplasiques
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Nat Prod
Année:
2011
Type de document:
Article
Pays d'affiliation:
Australie