Phenolic compounds with NF-κB inhibitory effects from the fungus Phellinus baumii.
Bioorg Med Chem Lett
; 21(11): 3261-7, 2011 Jun 01.
Article
de En
| MEDLINE
| ID: mdl-21531558
ABSTRACT
Chemical investigation of the fungus Phellinus baumii has resulted in characterization of five previously undescribed hispidin derivatives, phellibaumins A-E (1-5), as well as two pairs of new non-equivalent epimeric benzyl dihydroflavones, methylphelligrin A (9), epi-methylphelligrin A (10), methylphelligrin B (11), and epi-methylphelligrin B (12), together with five known compounds, interfungin B (6), phelligridin H (7), phelligridimer A (8), phelligrin A (13), and epi-phelligrin A (14). Phellibaumin A (1) was a novel hispidin derivative with a unique 3,4-dihydroxybenzofuran unit. These compounds exhibited NF-κB inhibitory activity with IC(50) values of 52.96 µM (1), 41.40 µM (2), 52.92 µM (5), 36.44 µM (9 and 10), and 22.46 µM (11 and 12), respectively.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Phénols
/
Tumeurs de la prostate
/
Basidiomycota
/
Facteur de transcription NF-kappa B
Type d'étude:
Prognostic_studies
Limites:
Humans
/
Male
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2011
Type de document:
Article