Folate-decorated nanogels for targeted therapy of ovarian cancer.
Biomaterials
; 32(23): 5417-26, 2011 Aug.
Article
de En
| MEDLINE
| ID: mdl-21536326
ABSTRACT
Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'ovaire
/
Systèmes de délivrance de médicaments
/
Hydrogels
/
Nanoparticules
/
Acide folique
/
Antinéoplasiques
Langue:
En
Journal:
Biomaterials
Année:
2011
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique