Synthesis of pyrrolidinoindolines from 2-(2-oxo-3-indolyl)acetates: scope and limitations.
Nat Prod Commun
; 6(4): 457-64, 2011 Apr.
Article
de En
| MEDLINE
| ID: mdl-21560758
ABSTRACT
A series of 1,3a,8-alkylpyrrolidinoindolines have been synthesized. The scope and limitations of the alkylation of starting methyl oxindol-3-acetates are explored employing electron-rich and electron-poor alkylating agents. Hydrolysis and reductive lactonization of the resulting carboxylic gamma-oxindolic acid derivatives proceeds with good yields to afford 2-oxofuroindolines providing ready access to the pyrrolidinoindoline derivatives.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyrrolidines
/
Indoles
/
Acétates
Langue:
En
Journal:
Nat Prod Commun
Sujet du journal:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Année:
2011
Type de document:
Article
Pays de publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA