Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study.
Int J Clin Pract
; 65(6): 679-83, 2011 Jun.
Article
de En
| MEDLINE
| ID: mdl-21564441
ABSTRACT
AIMS:
The impact of statins on glucose metabolism and adipokines remains controversial. We compared the effects of rosuvastatin and atorvastatin on glucose homeostasis, insulin sensitivity (IS), adiponectin and leptin levels as well as systemic inflammation in non-diabetic patients with dyslipidaemia.METHODS:
Thirty-six patients were randomly assigned to 10 mg/day of rosuvastatin (n = 18) or 20 mg/day of atorvastatin (n = 18) for 12 weeks. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TG), fasting plasma glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), quantitative IS check index (QUICKI), adiponectin, leptin and high-sensitivity C-reactive protein (hsCRP) were measured at baseline and after 4 and 12 weeks.RESULTS:
Both statins significantly lowered TC, LDL-C, non-HDL-C and TG compared with baseline. Only rosuvastatin caused a significant reduction in insulin and HOMA-IR levels (-35%, p = 0.005 and -33%, p = 0.011 respectively) and a significant increase in QUICKI (+11%, p = 0.003) at 12 weeks. In terms of adipokines and hsCRP, no difference was observed after 4 and 12 weeks of treatment with either statin.CONCLUSIONS:
Rosuvastatin compared with atorvastatin resulted in significant improvements in IS indices. No significant changes in adiponectin, leptin or hsCRP levels were observed at 4 and 12 weeks of treatment with either statin.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyrimidines
/
Pyrroles
/
Sulfonamides
/
Glycémie
/
Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
/
Dyslipidémies
/
Adipokines
/
Fluorobenzènes
/
Acides heptanoïques
Type d'étude:
Clinical_trials
/
Observational_studies
Limites:
Aged
/
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Int J Clin Pract
Sujet du journal:
MEDICINA
Année:
2011
Type de document:
Article
Pays d'affiliation:
Grèce