New cytotoxic oxygenated sterols from the marine bryozoan Cryptosula pallasiana.
Mar Drugs
; 9(2): 162-183, 2011 Jan 28.
Article
de En
| MEDLINE
| ID: mdl-21566793
ABSTRACT
Six new sterols (1-6), together with seven known sterols (7-13), were isolated from the CCl(4) extract of the marine bryozoan Cryptosula pallasiana, four (3-6) of which have already been reported as synthetic sterols. This is the first time that these compounds (3-6) are reported as natural sterols. The structures of the new compounds were determined on the basis of the extensive spectroscopic analysis, including two-dimensional (2D) NMR and HR-ESI-MS data. Compounds 1-4, 7 and 10-13 were evaluated for their cytotoxicity against HL-60 human myeloid leukemia cell line, and all of the evaluated compounds exhibited moderate cytotoxicity to HL-60 cells with a range of IC(50) values from 14.73 to 22.11 µg/mL except for compounds 12 and 13.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Stérols
/
Bryozoa
/
Antinéoplasiques
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mar Drugs
Sujet du journal:
BIOLOGIA
/
FARMACOLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND