Survival rates of children with acute lymphoblastic leukemia presenting to a pediatric rheumatologist in the United States.
J Pediatr Hematol Oncol
; 33(6): 424-8, 2011 Aug.
Article
de En
| MEDLINE
| ID: mdl-21572344
ABSTRACT
BACKGROUND:
Approximately 30% of pediatric acute lymphoblastic leukemia patients present with musculoskeletal symptoms and are often referred first to a pediatric rheumatologist. We examined the survival and causes of death of these patients presenting to a pediatric rheumatologist and compared the rates with that reported in the hematology-oncology literature. PROCEDURE We used the Pediatric Rheumatology Disease Registry, including 49,023 patients from 62 centers, newly diagnosed between 1992 and 2001. Identifiers were matched with the Social Security Death Index censored for March 2005. Deaths were confirmed by death certificates, referring physicians, and medical records. Causes of death were derived by chart review or from the death certificate.RESULTS:
There were 7 deaths of 89 patients (7.9%, 95% confidence interval 3.9%-15.4%) with acute lymphoblastic leukemia with a 5-year survival rate of 95.5% (88.3 to 98.3) and 10-year survival rate of 89.8% (79.0% to 95.2%). The causes of death were sepsis (bacterial and/or fungal) in 4 (57%) patients, the disease in 2 (29%) and post bone-marrow transplantation in 1 (14%).CONCLUSION:
The overall survival of patients with acute lymphoblastic leukemia seen first by pediatric rheumatologists is higher than the range reported in the pediatric oncology literature for the same period of diagnosis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arthrite juvénile
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Child
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
J Pediatr Hematol Oncol
Sujet du journal:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique