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ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Choi, Youn Soo; Kageyama, Robin; Eto, Danelle; Escobar, Tania C; Johnston, Robert J; Monticelli, Laurel; Lao, Christopher; Crotty, Shane.
Affiliation
  • Choi YS; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Immunity ; 34(6): 932-46, 2011 Jun 24.
Article de En | MEDLINE | ID: mdl-21636296
The nature of follicular helper CD4(+) T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation and the time at which Tfh cell differentiation occurs. Here we determine that Tfh cell development initiates immediately during dendritic cell (DC) priming in vivo. We demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5, the canonical feature of Tfh cells. Strikingly, a bifurcation between Tfh and effector Th cells was measurable by the second cell division of CD4(+) T cells, at day 2 after an acute viral infection: IL2Rα(int) cells expressed Bcl6 and CXCR5 (Tfh cell program), whereas IL2Rα(hi) cells exhibited strong Blimp1 expression that repressed Bcl6 (effector Th cell program). Virtually complete polarization between Bcl6(+) Tfh cells and Blimp1(+) effector Th cell populations developed by 72 hr, even without B cells. Tfh cells were subsequently lost in the absence of B cells, demonstrating a B cell requirement for maintenance of Bcl6 and Tfh cell commitment via sequential ICOS signals.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transcription génétique / Protéines / Différenciation cellulaire / Lymphocytes T auxiliaires / Protéines de liaison à l'ADN Limites: Animals Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2011 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Transcription génétique / Protéines / Différenciation cellulaire / Lymphocytes T auxiliaires / Protéines de liaison à l'ADN Limites: Animals Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2011 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique