Uterine neuroectodermal tumor with ependymoblastic features in an infant with clonal +del (2)(q11.2),-13: a possible role of increased gene dosage on 2pter-2q11.2 in the tumorigenesis.
Pediatr Dev Pathol
; 15(3): 226-31, 2012.
Article
de En
| MEDLINE
| ID: mdl-21815817
ABSTRACT
Clonal +(2)(q11.2),-13 was detected in a uterine neuroectodermal tumor with ependymoblastic features arising in an infant. The tumor expressed vimentin, nestin, CD56, CD99, microtubule-associated protein 1B (MAP 1B), focally microtubule-associated protein 2 (MAP 2), synaptophysin, neuron-specific enolase, and, very focally, epithelial membrane antigen. Because trisomy 2 was previously detected in a medulloepithelioma of pelvic soft tissue and in several neuroectodermal tumors of the central nervous system, this finding is indicative of a possible role of increased dosage of gene(s) on chromosome 2 in the tumorigenesis of these neoplasms and of their histogenetic relatedness.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'utérus
/
Chromosomes humains de la paire 2
/
Protocoles de polychimiothérapie antinéoplasique
/
Transformation cellulaire néoplasique
/
Tumeurs neuroectodermiques
Limites:
Female
/
Humans
/
Infant
Langue:
En
Journal:
Pediatr Dev Pathol
Sujet du journal:
PATOLOGIA
/
PEDIATRIA
Année:
2012
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique