[Obesity, insulin resistance and type 2 diabetes: risk factors for breast cancer]. / Obésité, insulinorésistance et diabète de type 2: facteurs de risque du cancer du sein.
Rev Med Liege
; 66(5-6): 238-44, 2011.
Article
de Fr
| MEDLINE
| ID: mdl-21826954
ABSTRACT
Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin-like-growth factor -IGF-, is a growth factor), hyperleptinaemia associated with hypoadiponectinaemia, and high levels of estrogens resulting from aromatization of androgens in adipose tissue. In presence of type 2 diabetes associated with obesity, hyperglycaemia might provide energy substrate promoting tumour growth. These data have therapeutic implications with expected favourable effects of weight loss, resulting in a reduction of fat mass and insulin resistance, and the promising results recently reported with metformin contrasting with the negative effects of exogenous administration of high doses of insulin.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du sein
/
Insulinorésistance
/
Diabète de type 2
/
Obésité
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
Langue:
Fr
Journal:
Rev Med Liege
Année:
2011
Type de document:
Article
Pays d'affiliation:
Belgique