The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.
Mol Immunol
; 27(3): 203-10, 1990 Mar.
Article
de En
| MEDLINE
| ID: mdl-2188119
ABSTRACT
Several distinctive features of anti-DNA autoantibodies have been identified by a detailed analysis of the available heavy and light chain sequences. They include unique VH gene segments that are not normally expressed in antibodies to external antigens, somatic mutations which may serve to change the antigenic specificity as well as to increase affinity, a less stringent choice of light chains, and a unique basic peptide in the heavy chain CDR3. It is proposed that in the majority of cases, the regulatory mechanism of self-tolerance in the healthy animal operates via VH gene expression to prevent the synthesis of potentially high affinity anti-DNA autoantibodies.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
ADN
/
Gènes d'immunoglobuline
/
Expression des gènes
/
Anticorps antinucléaires
/
Lupus érythémateux disséminé
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mol Immunol
Année:
1990
Type de document:
Article
Pays d'affiliation:
Israël