[Subchondral bone in osteoarthritis: a review].
Zhongguo Gu Shang
; 24(8): 702-4, 2011 Aug.
Article
de Zh
| MEDLINE
| ID: mdl-21928687
ABSTRACT
Osteoarthritis (OA) is the most prevalent of joint diseases,and its pathology is characterized by the degeneration of cartilage, sclerosis of subchondral bone, and osteophyte formation. Localization of the early lesions of OA has not been clarified, but many researchers have focused on cartilage and have considered that changes in subchondral bone occur subsequently to the degeneration of cartilage. However, a low bone mineral density, particularly in the knee joint with OA, high bone turnover, and efficacy of bone resorption inhibitors for OA have recently been reported, suggesting that subchondral bone plays an important role in the pathogenesis of OA. This review aims to make a conclusion about advancement in research of subchondral bone in osteoarthritis.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arthrose
/
Os et tissu osseux
/
Cartilage
Type d'étude:
Etiology_studies
Limites:
Humans
Langue:
Zh
Journal:
Zhongguo Gu Shang
Sujet du journal:
ORTOPEDIA
/
TRAUMATOLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
Chine