Comparison of an acellular pertussis-component diphtheria-tetanus-pertussis (DTP) vaccine with a whole-cell pertussis-component DTP vaccine in 17- to 24-month-old children, with measurement of 69-kilodalton outer membrane protein antibody.
J Pediatr
; 117(1 Pt 1): 46-51, 1990 Jul.
Article
de En
| MEDLINE
| ID: mdl-2196360
ABSTRACT
Healthy 17- to 24-month-old children, previously immunized with three doses of whole-cell diphtheria-tetanus-pertussis (DTP) vaccine, were enrolled in a multi-center double-blind, randomized study comparing a DTP vaccine with an acellular pertussis-component (APDT) and a conventional whole-cell pertussis-component DTP vaccine. Thirty-eight children received APDT vaccine, and 37 children received DTP vaccine. APDT vaccine recipients had significantly less local pain and warmth than DTP vaccine recipients. Antibody responses to lymphocytosis-promoting factor were similar in the two groups. The APDT vaccine recipients had a higher IgG antibody response to filamentous hemagglutinin than the DTP vaccinees had. Equivalent agglutinin responses were seen in the two groups. The APDT vaccine recipients had a significantly better antibody re-enzyme-linked immunosorbent assay, than DTP vaccinees had 1 month and 1 year after immunization. This APDT vaccine was immunogenic and caused fewer local reactions than conventional DTP vaccine when administered as a fourth dose to 17- to 24-month-old children.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vaccin diphtérie-tétanos-coqueluche
/
Anticorps antibactériens
Type d'étude:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Humans
/
Infant
Langue:
En
Journal:
J Pediatr
Année:
1990
Type de document:
Article