An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.
Nat Immunol
; 12(11): 1071-7, 2011 Oct 09.
Article
de En
| MEDLINE
| ID: mdl-21983833
ABSTRACT
Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pneumopathie infectieuse
/
Lymphocytes
/
Cytokines
/
Interleukine-9
/
Lymphocytes auxiliaires Th2
Limites:
Animals
Langue:
En
Journal:
Nat Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
Royaume-Uni