Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.
Nat Immunol
; 12(12): 1202-11, 2011 Oct 30.
Article
de En
| MEDLINE
| ID: mdl-22037601
ABSTRACT
Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other inflammatory processes, and these cells can be activated through their T cell antigen receptors by microbial lipid antigens. However, increasing evidence shows that they are also activated in situations in which foreign lipid antigens would not be present, which suggests a role for lipid self antigen. We found that an abundant endogenous lipid, ß-D-glucopyranosylceramide (ß-GlcCer), was a potent iNKT cell self antigen in mouse and human and that its activity depended on the composition of the N-acyl chain. Furthermore, ß-GlcCer accumulated during infection and in response to Toll-like receptor agonists, contributing to iNKT cell activation. Thus, we propose that recognition of ß-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Autoantigènes
/
Infections bactériennes
/
Glycosphingolipides
/
Cellules T tueuses naturelles
Limites:
Animals
/
Humans
Langue:
En
Journal:
Nat Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2011
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique