Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.
Hum Exp Toxicol
; 31(4): 397-404, 2012 Apr.
Article
de En
| MEDLINE
| ID: mdl-22076497
ABSTRACT
Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8-hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pancréatite
/
Phénols
/
Stress oxydatif
/
Benzodioxoles
/
Antioxydants
Limites:
Animals
Langue:
En
Journal:
Hum Exp Toxicol
Sujet du journal:
TOXICOLOGIA
Année:
2012
Type de document:
Article
Pays d'affiliation:
Taïwan