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Pelvic surgery and hospitalization among Chilean women after nonsurgical sterilization with quinacrine pellets between 1977 and 1989.
Feldblum, Paul J; Wheeless, Angie; Trujillo, Valentin; Guzman, Sergio; Halpern, Vera; Sokal, David C.
Affiliation
  • Feldblum PJ; FHI 360, P.O. Box 13950, Research Triangle Park, NC 27709, USA.
Contraception ; 86(2): 106-9, 2012 Aug.
Article de En | MEDLINE | ID: mdl-22240176
ABSTRACT

BACKGROUND:

Concern about quinacrine lingers because of its carcinogenic effects in rats. We describe results of long-term follow-up of women who underwent quinacrine pellet sterilization in Chile between 1977 and 1989 (N=1492).

METHODS:

We interviewed the women or relatives in five rounds of data collection between 1991-1993 and 2006-2007, and reviewed hospital records. Median follow-up was 18.5 years; total person-time was 23,894 woman-years. This analysis focuses on pelvic and abdominal surgeries and conditions. We used survival analysis to estimate the 15-year cumulative probability of hysterectomy, other pelvic surgical procedures and relevant adverse events.

RESULTS:

Uterine fibroids were by far the most common gynecologic condition, reported by 11% of the cohort. Surgical procedures were recorded for 15% of the cohort; hysterectomy was the most frequent procedure (10%), followed by salpingectomy (2%). The 15-year probability of any pelvic or abdominal procedure was 14.7 per 100 women (95% confidence interval 12.4-16.9). The probability of hysterectomy was 9.3 per 100 women (95% confidence interval 7.4-11.1). Number of quinacrine insertions had little impact on the probabilities.

CONCLUSION:

During long-term follow-up of women who received quinacrine pellets for nonsurgical sterilization, the incidence of noncancer adverse outcomes was not unusually high, and no alarming patterns emerged.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pelvis / Mépacrine / Agents régulateurs de la reproduction / Stérilisation contraceptive / Tumeurs de l'appareil génital féminin Type d'étude: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Female / Humans / Middle aged Pays/Région comme sujet: America do sul / Chile Langue: En Journal: Contraception Année: 2012 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pelvis / Mépacrine / Agents régulateurs de la reproduction / Stérilisation contraceptive / Tumeurs de l'appareil génital féminin Type d'étude: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Female / Humans / Middle aged Pays/Région comme sujet: America do sul / Chile Langue: En Journal: Contraception Année: 2012 Type de document: Article Pays d'affiliation: États-Unis d'Amérique