Integrated dataset of screening hits against multiple neglected disease pathogens.
PLoS Negl Trop Dis
; 5(12): e1412, 2011 Dec.
Article
de En
| MEDLINE
| ID: mdl-22247786
New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies parasitaires
/
Évaluation préclinique de médicament
/
Maladies négligées
/
Antiparasitaires
Type d'étude:
Diagnostic_studies
/
Screening_studies
Limites:
Humans
Langue:
En
Journal:
PLoS Negl Trop Dis
Sujet du journal:
MEDICINA TROPICAL
Année:
2011
Type de document:
Article
Pays d'affiliation:
Suisse
Pays de publication:
États-Unis d'Amérique