[Polyanionic inhibitors of HIV adsorption].
Bioorg Khim
; 37(5): 592-608, 2011.
Article
de Ru
| MEDLINE
| ID: mdl-22332354
ABSTRACT
Viral adsorption inhibitors represent new generation of antiviral drugs, which can be applied for the treatment of HIV infection. Given review presents the different classes of HIV entry inhibitors grouped by the processes they are targeted the binding of viral glycoprotein gp120 with cellular receptor CD4, the following interaction of gp120 with the chemokine receptors CCR5 or CXCR4, the formation of six-helix bundle gp41 needed for the viral and cellular membrane fusion.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymères
/
Protéine d'enveloppe gp41 du VIH
/
Protéine d'enveloppe gp120 du VIH
/
Infections à VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Récepteurs aux chimiokines
/
Inhibiteurs de fusion du VIH
Limites:
Humans
Langue:
Ru
Journal:
Bioorg Khim
Année:
2011
Type de document:
Article