[11C]choline PET for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT.
Q J Nucl Med Mol Imaging
; 56(2): 202-8, 2012 Apr.
Article
de En
| MEDLINE
| ID: mdl-22402821
ABSTRACT
AIM:
This study focuses on the potential role of [11C]choline positron emission tomography (PET) for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT.METHODS:
This retrospective study was conducted in patients who were being followed up after EBRT for histological proven prostate cancer. We selected the patients with a local recurrence by [11C]choline PET/CT fusion. The results of PET were compared with the results of histology and with clinical follow-up.RESULTS:
Forty-two patients with a local recurrence suggested by PET were included in this study. According to PETresults:
of the 42 patients, 15 (36%) had a focal recurrence, 27 (64%) showed a diffuse recurrence. The overall concordance of PET with histology concerning detection of recurrence was 76% (32 patients had positive PET results and positive biopsies). We confirmed the local recurrence as visualized by PET in 37/42 (88%) patients using a composite reference with histology and clinical follow up after local salvage treatment. The concordance of the intraprostatic distribution of the tumor with PET with histology from transrectal prostate biopsies (median biopsies 7, range 4-12) was 47% (7/15) in unilateral cases and 41% (11/27) in bilateral cases. No significant differences were seen between the 2 groups in serum PSA at time of PET (P=0.509) and SUV (P=0.739) using Student's t-test.CONCLUSION:
Intraprostatic characterization of recurrent prostate cancer after EBRT with 11C-choline PET is feasible at present but shows a moderate concordance with routine transrectal prostate biopsies. The accuracy is too low for the routine use of this modality in the present scenario.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de la prostate
/
Choline
/
Radiothérapie conformationnelle
/
Tomographie par émission de positons
/
Récidive tumorale locale
Type d'étude:
Diagnostic_studies
/
Observational_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Q J Nucl Med Mol Imaging
Sujet du journal:
MEDICINA NUCLEAR
Année:
2012
Type de document:
Article
Pays d'affiliation:
Pays-Bas