Rapid test for fecal calprotectin levels in children with Crohn disease.
J Pediatr Gastroenterol Nutr
; 55(4): 436-9, 2012 Oct.
Article
de En
| MEDLINE
| ID: mdl-22411269
ABSTRACT
Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100 µg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie de Crohn
/
Complexe antigénique L1 leucocytaire
/
Fèces
/
Inflammation
Type d'étude:
Clinical_trials
/
Prognostic_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Langue:
En
Journal:
J Pediatr Gastroenterol Nutr
Année:
2012
Type de document:
Article
Pays d'affiliation:
Finlande